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KMID : 0861020000150020101
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Korea Journal of Herbology
2000 Volume.15 No. 2 p.101 ~ p.109
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The Effects of the Extracts from Xanthii Fructus about the Anti - allergic Action on IC - 2 Cells
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Abstract
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In order to investigate the immunosuppressant effects of Xanthii Fructus and about the expression of CD23, IgE and IL-4, it was necessary for it to be activated by phorbol 12-myristate 13-acetate (PMA) and ionomycin. We then analyzed it from the flow cytometry on the increase and the divorce of the B cells activated by anti-CD40.
The results were obtained as follows:
1. The extracts of Xanthii Fructus significantly decreased the expression of anti-CD23.
2. The extracts of Xanthii Fructus in combination with PMA, inonmycin decreased the expression of anti-CD23 as compared with PMA, ionomycin.
3. The extracts of Xanthii Fructus in combination with IL-4 reduced the expression of anti-CD23 as compared with IL-4
above results demonstrates that the extracts of Xanthii Fructus suppresss the expression anti-CD23 by suppressing activities of B cells and control anti-IgE by suppressing activities of B cells activated by PMA, ionomycin, IL-4.
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KEYWORD
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